Brandoch Cook Ph.D.
brc2018@med.cornell.edu
Instructor of Cell and Developmental Biology
Department of Surgery
My projects in the laboratory primarily involve the creation of loss-of-function models in mouse embryonic stem cells and zebrafish using conditional transgenic expression of interfering RNA hairpins. I am currently using these systems to examine the role of BMP effector molecules, particularly the SMAD family of transcription factors, in primitive and definitive hematopoeisis.
brc2018@med.cornell.edu
Instructor of Cell and Developmental Biology
Department of Surgery
My projects in the laboratory primarily involve the creation of loss-of-function models in mouse embryonic stem cells and zebrafish using conditional transgenic expression of interfering RNA hairpins. I am currently using these systems to examine the role of BMP effector molecules, particularly the SMAD family of transcription factors, in primitive and definitive hematopoeisis.
Education
|
PhD
MS BA |
Sackler Institute of Biomedical Sciences
Sackler Institute of Biomedical Sciences University of Colorado |
2008
2002 1996 |
Publications
Cook, B.D. and Evans, T. (2014). BMP Signaling Balances Murine Myeloid Potential Through SMAD-independent p38MAPK and NOTCH Pathways. Blood. 124: 393-402.
Cook, B.D. (2014). Modeling murine yolk sac hematopoiesis with embryonic stem cell culture systems. Front Biol (Beijing). 9(5):339-346.
Cook, B.D., Liu, S. and Evans, T. (2011). Smad1 Signaling Restricts Hematopoietic Potential after Promoting Hemangioblast Expansion. Blood. 117: 6489-6497. PMID: 21515822.
Ferrari G, Cook BD, Terushkin V, Pintucci G, Mignatti P. (2009) Transforming growth factor-beta 1 (TGF-beta1) induces angiogenesis through vascular endothelial growth factor (VEGF)-mediated apoptosis. J Cell Physiol. 219(2):449-58.
Cook BD, Ferrari G, Pintucci G, Mignatti P. (2008) TGF-beta1 induces rearrangement of FLK-1-VE-cadherin-beta-catenin complex at the adherens junction through VEGF-mediated signaling. J Cell Biochem. 105(6):1367-73. Featured Article
Cook, B.D. (2014). Modeling murine yolk sac hematopoiesis with embryonic stem cell culture systems. Front Biol (Beijing). 9(5):339-346.
Cook, B.D., Liu, S. and Evans, T. (2011). Smad1 Signaling Restricts Hematopoietic Potential after Promoting Hemangioblast Expansion. Blood. 117: 6489-6497. PMID: 21515822.
Ferrari G, Cook BD, Terushkin V, Pintucci G, Mignatti P. (2009) Transforming growth factor-beta 1 (TGF-beta1) induces angiogenesis through vascular endothelial growth factor (VEGF)-mediated apoptosis. J Cell Physiol. 219(2):449-58.
Cook BD, Ferrari G, Pintucci G, Mignatti P. (2008) TGF-beta1 induces rearrangement of FLK-1-VE-cadherin-beta-catenin complex at the adherens junction through VEGF-mediated signaling. J Cell Biochem. 105(6):1367-73. Featured Article