Karen Mendelson
kam2030@med.cornell.edu
Postdoctoral Fellow
Co-Mentorship with Timothy Hla, PhD
My research is focused on uncovering the role of sphingosine 1 phosphate signaling in a zebrafish model.
kam2030@med.cornell.edu
Postdoctoral Fellow
Co-Mentorship with Timothy Hla, PhD
My research is focused on uncovering the role of sphingosine 1 phosphate signaling in a zebrafish model.
Education
|
PhD
MA BA |
Weill Cornell Graduate School of Medical Sciences
Boston University Princeton University |
2010
2004 2003 |
Publications
Mendelson K., Lan Y., Hla T., Evans T. (2015). Maternal or zygotic sphingosine kinase is required to regulate zebrafish cardiogenesis. Dev Dyn. 2015 May 22. PMID 25997406
Mendelson, K., Evans, T., and Hla, T. (2014). Sphingosine-1-phosphate Signaling in Development. Development. 141: 5-9.
Mendelson, K., Zygmunt, T., Torres-Vazquez, J., Evans*, T., and Hla*, T. (2013). Sphingosine-1-Phosphate Receptor Signaling Regulates Proper Embryonic Vascular Patterning. J. Biol. Chem. 288: 2143-2156.
Jung, B., Obinata, H., Galvani, S., Mendelson, K., Ding, B., Skoura, A., Kinzel, B., Brinkmann, V., Rafii, S., Evans, T., and Hla T. (2012). Flow-regulated Intravascular S1P Signaling Sustains Angiogenesis. Dev. Cell. 23: 600-610. PMID: 22975328.
Torregroza, I., Holtzinger, A., Mendelson K., Liu, T.-C., Hla, T., and Evans, T. (2012). Regulation of a Vascular Plexus by gata4 is Mediated in Zebrafish through the Chemokine sdf1a. PLoS ONE. 7: e46844. PMID: 23056483.
Mendelson K, Swendeman S, Saftig, P, and Blobel CP. (2010) Stimulation of the PDGFRI activates ADAM17 and promotes metalloproteinase-dependent crosstalk between the PDGFRI and EGFR signaling pathways. J. Biol. Chem. 285:25024-25032.
Weskamp G, Mendelson K, Swendeman S, Le Gall S, Ma Y, Lyman S, Hinoki A, Eguchi S, Guaiquil V, Horiuchi K, and Blobel CP. (2010) Pathological neovascularization is reduced by inactivation of ADAM17 in endothelial cells, but not in pericytes. Circ Res. 106:932-940.
Swendeman S, Mendelson K, Weskamp G, Horiuchi K, Deutsch U, Scherle P, Hooper A, Rafii S, Blobel CP. (2008) VEGF-A Stimulates ADAM17-Dependent Shedding of VEGFR2 and Crosstalk Between VEGFR2 and ERK Signaling. Circ Res. 103:916-918.
Mettler BA, Sales VL, Stucken CL, Anttila V, Mendelson K, Bischoff J, Mayer JE Jr. (2008) Stem cell-derived, tissue-engineered pulmonary artery augmentation patches in vivo. Ann Thorac Surg. 86:132-140.
Mendelson K., Aikawa E., Mettler B., Sales V., Martin D., Mayer J., Schoen F. (2007) Healing and remodeling of bioengineered pulmonary artery patches implanted in sheep. Cardiovasc Pathol. 16:277-282.
Mendelson K. and Schoen F. Heart Valve Tissue Engineering: Approaches, Progress, and Challenges. (2006) Annals of Biomedical Engineering. 34:1799-1819.
Aikawa E., Whittaker P., Farber M., Mendelson K., Padera R., Aikawa M., Schoen F. Human (2006) Semilunar Cardiac Valve Remodeling by Activated Cells from Fetus to Adult: Implications for Postnatal Adaptation, Valve Pathology and Tissue Engineering. Circulation. 113:1344-1352.
Wilson-Fritch L., Burkart A., Bell G., Mendelson K., et al. (2003) Mitochondrial Biogenesis and Remodeling During Adipogenesis and in Response to the Insulin Sensitizer Rosiglitazone. Molecular and Cellular Biology. 23:1085-1094.
Mendelson, K., Evans, T., and Hla, T. (2014). Sphingosine-1-phosphate Signaling in Development. Development. 141: 5-9.
Mendelson, K., Zygmunt, T., Torres-Vazquez, J., Evans*, T., and Hla*, T. (2013). Sphingosine-1-Phosphate Receptor Signaling Regulates Proper Embryonic Vascular Patterning. J. Biol. Chem. 288: 2143-2156.
Jung, B., Obinata, H., Galvani, S., Mendelson, K., Ding, B., Skoura, A., Kinzel, B., Brinkmann, V., Rafii, S., Evans, T., and Hla T. (2012). Flow-regulated Intravascular S1P Signaling Sustains Angiogenesis. Dev. Cell. 23: 600-610. PMID: 22975328.
Torregroza, I., Holtzinger, A., Mendelson K., Liu, T.-C., Hla, T., and Evans, T. (2012). Regulation of a Vascular Plexus by gata4 is Mediated in Zebrafish through the Chemokine sdf1a. PLoS ONE. 7: e46844. PMID: 23056483.
Mendelson K, Swendeman S, Saftig, P, and Blobel CP. (2010) Stimulation of the PDGFRI activates ADAM17 and promotes metalloproteinase-dependent crosstalk between the PDGFRI and EGFR signaling pathways. J. Biol. Chem. 285:25024-25032.
Weskamp G, Mendelson K, Swendeman S, Le Gall S, Ma Y, Lyman S, Hinoki A, Eguchi S, Guaiquil V, Horiuchi K, and Blobel CP. (2010) Pathological neovascularization is reduced by inactivation of ADAM17 in endothelial cells, but not in pericytes. Circ Res. 106:932-940.
Swendeman S, Mendelson K, Weskamp G, Horiuchi K, Deutsch U, Scherle P, Hooper A, Rafii S, Blobel CP. (2008) VEGF-A Stimulates ADAM17-Dependent Shedding of VEGFR2 and Crosstalk Between VEGFR2 and ERK Signaling. Circ Res. 103:916-918.
Mettler BA, Sales VL, Stucken CL, Anttila V, Mendelson K, Bischoff J, Mayer JE Jr. (2008) Stem cell-derived, tissue-engineered pulmonary artery augmentation patches in vivo. Ann Thorac Surg. 86:132-140.
Mendelson K., Aikawa E., Mettler B., Sales V., Martin D., Mayer J., Schoen F. (2007) Healing and remodeling of bioengineered pulmonary artery patches implanted in sheep. Cardiovasc Pathol. 16:277-282.
Mendelson K. and Schoen F. Heart Valve Tissue Engineering: Approaches, Progress, and Challenges. (2006) Annals of Biomedical Engineering. 34:1799-1819.
Aikawa E., Whittaker P., Farber M., Mendelson K., Padera R., Aikawa M., Schoen F. Human (2006) Semilunar Cardiac Valve Remodeling by Activated Cells from Fetus to Adult: Implications for Postnatal Adaptation, Valve Pathology and Tissue Engineering. Circulation. 113:1344-1352.
Wilson-Fritch L., Burkart A., Bell G., Mendelson K., et al. (2003) Mitochondrial Biogenesis and Remodeling During Adipogenesis and in Response to the Insulin Sensitizer Rosiglitazone. Molecular and Cellular Biology. 23:1085-1094.